The capsule has a long history. As early as the 1500 BC, Gelatin Hollow Capsules the first capsule was born in Egypt; in 1730, Viennese pharmacists began making capsules from starch; In 1834, capsule manufacturing technology was patented in Paris; In 1846, the two-section hard capsule manufacturing technology was patented in France; Gelatin Hollow Capsules In 1872, the first capsule-making filling machine was born in France; in 1874, the Detroit began the industrialized manufacture of hard capsules in the United States and introduced various models.
Capsules, usually with hard capsules and soft capsules. Gelatin Hollow Capsules The hard capsule is also called the Hollow Capsule, which is composed of two parts of the cap body, and the soft capsule is processed into a product at the same time as the film material and contents. Gelatin Hollow Capsules According to the raw materials, hollow capsules generally include: gelatin hollow capsules and Plant hollow capsules. At present, Gelatin Hollow Capsules the large-scale production of Plant hollow capsules is mainly hydroxypropyl methyl cellulose (HPMC) plant capsules, so the domestic hollow capsules are mainly gelatin hollow capsules and Hydroxypropyl Cellulose (HPMC) plant capsules.
First, the use of raw materials is different. Gelatin Hollow capsules are mainly composed of high-quality medicinal gelatin, gelatin from animal skin, tendons, bone collagen, Gelatin Hollow Capsules is from the animal connective tissue or epidermal tissue of the collagen part of hydrolysis to protein. The main ingredient of hydroxypropyl cellulose (HPMC) plant capsules is hydroxypropyl methyl cellulose, Gelatin Hollow Capsules which is usually made of cellulose by plant hydrolysis. As a result of religious beliefs (Judaism, Islam, etc.), dietary habits (vegetarianism), Gelatin Hollow Capsules the need for green nature and the prevention of animal-borne diseases (BSE), the use of Hydroxypropyl Cellulose (HPMC) capsules has increased throughout the world.
Secondly, the structural stability of the shell is different. The residual lysine in gelatin, Gelatin Hollow Capsules the adjacent lysine residues, the aldehyde group, and the aldehyde amine condensation reaction to produce pyridine ring and crosslinking effect, therefore, using gelatin as the capsule, Gelatin Hollow Capsules the capsules have disintegration and delay phenomenon in the process of placement. And HPMC is a part of cellulose methyl and some of the poly hydroxypropyl ether, the chemical property is stable, Gelatin Hollow Capsules do not occur cross-linking, so there will be no disintegration delay phenomenon. In addition, the contents of aldehydes, reducing sugar base compounds and vitamin C and other groups will react with amino or carboxyl in gelatin, Gelatin Hollow Capsules not only affect the disintegration of the capsule and the stability of the drug, Gelatin Hollow Capsules so the drug is not suitable for the use of Gelatin hollow capsules. Gelatin contains carboxyl and amino groups, so the shell will have electrostatic effect, in the process of drug filling, the capsule shell easily occur adhesion and easy adsorption content. Gelatin Hollow Capsules and Hydroxypropyl Cellulose (HPMC) Plant capsule shell Electrostatic action small or no electrostatic action.