The history of the capsule is very long. As early as 1500 BC, Gelatin Hollow Capsules the first capsule was born in Egypt; in 1730, Vienna pharmacists began to use starch to create capsules; 1834, capsule manufacturing technology in Paris patent; 1846, two-section hard capsule manufacturing technology In France in 1876, in France, the birth of the first capsule manufacturing filling machine; in 1874, Gelatin Hollow Capsules in the United States began in the United States Detroit hard capsule industrial manufacturing, and introduced a variety of models
Capsules, usually with hard capsules and soft capsules. Gelatin Hollow Capsules Hard capsule, Gelatin Hollow Capsules also known as hollow capsule, consists of two parts of the cap body; soft capsule is the film forming materials and the contents of the product processed into the same time. According to raw materials, hollow capsules generally include: gelatin hollow capsules and plant hollow capsules. At present, Gelatin Hollow Capsules China has formed a large-scale production of plant hollow capsule is mainly hydroxypropyl methyl cellulose (HPMC) plant capsules, so the current domestic hollow capsules are mainly gelatin hollow capsules and hydroxypropyl methyl cellulose (HPMC) plant capsules.
Use different raw materials. Gelatin hollow capsule is the main component of high quality medicinal gelatin, gelatin derived from animal skin, tendons, bone collagen, is from the animal connective tissue or epidermal tissue collagen partial hydrolysis of the protein. The main component of the hydroxypropyl methylcellulose (HPMC) plant capsule is 2-hydroxypropylmethylcellulose, usually made from plant hydrolyzed cellulose, Gelatin Hollow Capsules made by etherification. Because of the religious belief (Jewish, Islam, etc.), eating habits (vegetarianism), advocating green natural needs and prevention of animal-borne diseases (mad cow disease), hydroxypropyl methylcellulose (HPMC) plant capsules are used globally The amount of rising year by year.
The structural stability of the capsule is different. Gelatin residues in the gelatin, Gelatin Hollow Capsules the adjacent lysine residues oxidize deamination to form acetaldehyde groups, and aldehyde amine condensation reaction to form pyridine ring and cross-linking effect, so the use of gelatin as a capsule, the capsule in the process of placing There is disintegration delay phenomenon. And HPMC for the cellulose part of the methyl and part of the polyhydroxypropyl ether, chemical stability, does not occur cross-linking effect, it will not have the phenomenon of disintegration delay. In addition, some of the groups containing aldehydes, Gelatin Hollow Capsules reducing glycosyl compounds and vitamin C in the contents react with the amino or carboxyl groups in the gelatin, affecting both the disintegration of the capsules and the stability of the drug. Suitable for gelatin hollow capsules. Gelatin contains carboxyl and amino groups, so the shell will have electrostatic effects, Gelatin Hollow Capsules in the drug filling process, the capsule prone to adhesion and easy to adsorb the contents. Gelatin Hollow Capsules And hydroxypropyl methyl cellulose (HPMC) plant capsule capsule electrostatic effect of small or no electrostatic effect.