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Gelatin Hollow Capsules Structural Stability Is Different
Oct 12, 2017

Capsules, usually with hard capsules and soft capsules. Gelatin Hollow Capsules Hard capsule, also known as hollow capsule, consists of two parts of the cap body; soft capsule is the film forming materials and the contents of the product processed into the same time. According to raw materials, hollow capsules generally include: gelatin hollow capsules and plant hollow capsules. At present, Gelatin Hollow Capsules China has formed a large-scale production of plant hollow capsule is mainly hydroxypropyl methyl cellulose (HPMC) plant capsules, so the current domestic hollow capsules are mainly gelatin hollow capsules and hydroxypropyl methyl cellulose (HPMC) plant capsules.

First, the use of raw materials is different. Gelatin hollow capsule is the main component of high quality medicinal gelatin, gelatin derived from animal skin, tendons, Gelatin Hollow Capsules bone collagen, is from the animal connective tissue or epidermal tissue collagen partial hydrolysis of the protein. The main component of the hydroxypropyl methylcellulose (HPMC) plant capsule is 2-hydroxypropylmethylcellulose, usually made from plant hydrolyzed cellulose, made by etherification. Because of the religious belief (Jewish, Islam, etc.), Gelatin Hollow Capsules eating habits (vegetarianism), advocating green natural needs and prevention of animal-borne diseases (mad cow disease), hydroxypropyl methylcellulose (HPMC) plant capsules are used globally The amount of rising year by year.

Second, the structural stability of the capsule is different. Gelatin residues in the gelatin, the adjacent lysine residues oxidize deamination to form acetaldehyde groups, and aldehyde amine condensation reaction to form pyridine ring and cross-linking effect, so the use of gelatin as a capsule, Gelatin Hollow Capsules the capsule in the process of placing There is disintegration delay phenomenon. And HPMC for the cellulose part of the methyl and part of the polyhydroxypropyl ether, chemical stability, does not occur cross-linking effect, it will not have the phenomenon of disintegration delay. In addition, some of the groups containing aldehydes, reducing glycosyl compounds and vitamin C in the contents react with the amino or carboxyl groups in the gelatin, Gelatin Hollow Capsules affecting both the disintegration of the capsules and the stability of the drug. Suitable for gelatin hollow capsules. Gelatin contains carboxyl and amino groups, so the shell will have electrostatic effects, in the drug filling process, the capsule prone to adhesion and easy to adsorb the contents. And hydroxypropyl methyl cellulose (HPMC) plant capsule capsule electrostatic effect of small or no electrostatic effect.

Water content is different. Gelatin Hollow Capsules The water content of gelatin hollow capsule capsule is about 13% ~ 15% under the condition of 20 ~ 25 ℃ and RH 40% ~ 60%, and under this condition, the content of hypocrellin (HPMC) Water is about 4% to 6%. Gelatin hollow capsules contain less than 10% moisture content, and hydroxypropyl methylcellulose (HPMC) plant capsule capsules even if the water content of 1% will become brittle. The high water content has a great influence on the stability of the wet sensitive drug. Gelatin Hollow Capsules If the moisture content is strong, if the gelatin hollow capsule is used, the moisture will migrate from the capsule to the contents, and the moisture content of the capsule will become hard and brittle, leading to the disintegration delay, and the use of hypromellose (HPMC) Capsules do not have this phenomenon.

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