The history of the capsule is very long. As early as 1500 BC, the first capsule was born in Egypt; in 1730, Vienna pharmacists began to use starch to create capsules; 1834, capsule manufacturing technology in Paris patent; 1846, two-section hard capsule manufacturing technology In France in 1872, in France, Gelatin Hollow Capsules the birth of the first capsule manufacturing filling machine; 1874, in the United States began in the United States Detroit hard capsule industrial manufacturing, while the introduction of various models.
Capsules, usually with hard capsules and soft capsules. Hard capsule, also known as hollow capsule, consists of two parts of the cap body; soft capsule is the film forming materials and the contents of the product processed into the same time. According to raw materials, Gelatin Hollow Capsules hollow capsules generally include: gelatin hollow capsules and plant hollow capsules. At present, China has formed a large-scale production of plant hollow capsule is mainly hydroxypropyl methyl cellulose hollow capsule, so the current domestic hollow capsule is mainly gelatin hollow capsule and hypromellose (HPMC) hollow capsule, the following two Hollow capsules were compared.
First, the use of raw materials is different. Gelatin Hollow Capsules Gelatin hollow capsule is the main component of high quality medicinal gelatin, gelatin derived from animal skin, tendons, bone collagen, is from the animal connective tissue or epidermal tissue collagen partial hydrolysis of the protein. HPMC hollow capsule is the main component of 2-hydroxypropyl methyl cellulose, usually produced by the hydrolysis of cellulose plant, made by etherification. As a result of religious beliefs (Jewish, Islam, etc.), Gelatin Hollow Capsules eating habits (vegetarianism), advocating green natural needs and the prevention of animal-borne diseases (mad cow disease), plant capsules in the global use of increased year by year.
Gelatin hollow capsule water content is generally 12.5% -17.5% . The temperature and humidity of the environment should be controlled within a suitable range both in the production, transportation, use and preservation of the hollow capsule. The appropriate temperature of 15-25 ℃, Gelatin Hollow Capsules relative humidity of 35% -65%, so that long-term to maintain product performance. The HPMC membrane contains very low moisture, typically 4% to 5%, Gelatin Hollow Capsules which is about 60% lower than the water content of gelatin hollow capsules (Fig. 1). The exchange of water with the environment during long periods of storage will increase the water content of the HPMC Hollow Capsules in the specified packaging, but will not exceed 9% in 5 years.
Gelatin film has a specified moisture content, Gelatin Hollow Capsules if below this limit, gelatin film will be obvious fragile. The gelatin hollow capsules without any additives have a brittle risk of 10% or more when the moisture content is 10%.Gelatin Hollow Capsules When the moisture content is continuously reduced to 5%, 100% of the fragile is present. In contrast, HPMC hollow capsules are much more resilient and maintain good performance even if the ambient humidity is low (Fig. 3). Of course, the incidence of fragmentation of HPMC hollow capsules at low humidity will vary widely.