In the centuries-old history of capsules, gelatin with its wide range of sources, stable physical and chemical properties and excellent processing performance has been to maintain the status of the mainstream capsule. Medicinal Hollow Capsule Shell With the increasing preference for capsules, hollow capsules are more widely used in the fields of food, pharmaceuticals and health products.
However, the occurrence and spread of mad cow disease and foot and mouth disease has led to concerns about animal-derived products. The most common raw material for gelatin is the bones and skins of cattle and pigs, and the risks are gradually being paid attention to. Medicinal Hollow Capsule Shell In order to reduce the safety risk of hollow capsule raw materials, industry experts continue to research and develop appropriate plant-derived cysts.
In addition, with the increase in the variety of capsules, the diversity of its contents has gradually made it clear that gelatin hollow capsules and some special nature of the contents of the compatibility problems. For example, containing aldehydes or under certain conditions to produce aldehyde content, Medicinal Hollow Capsule Shell may lead to gelatin cross-linking; reducible content, may be associated with gelatin reaction (MailardReaction ); Moisture content of the contents of the capsule will make the capsule water loss, loss of the original toughness.
People have tried a lot. Chinese Patent Application Publication No. 200810061238. applied for the use of sodium sulfate as the main capsule; 200510013285.3 applied to starch or starch composition as the main capsule; WangGM  reported chitosan capsule raw materials to create hollow capsules; Of course, Medicinal Hollow Capsule Shell the most studied or cellulose material. Medicinal Hollow Capsule Shell Among them, hydroxypropyl methyl cellulose (HPMC) made of hollow capsule has formed large-scale production.
HPMC is widely used in the field of food and medicine, is a commonly used pharmaceutical excipients, the national pharmacopoeia are contained; FDA and the European Union approved HPMC as a direct or indirect food additives; GRAS contained as a safety substance, Medicinal Hollow Capsule Shell No. GRN000213; JECFA database included, INSNo.464, did not limit the amount of HPMC daily dose limit; 1997 China's Ministry of Health approved it as food additives, thickeners, Medicinal Hollow Capsule Shell applicable to all types of food, Production requirements. Medicinal Hollow Capsule Shell Due to the difference in gelatin properties, HPMC hollow capsules are more complex and require the addition of some gelling agents such as gum arabic, carrageenan (algae), starch and so on.